Alternative Promoters

This page is an overview on both main paper analysis relating to alternative promoters and related expression information. The goal is to list/make available

• Methods and datasets
• Interest groups focusing on certain tissues/gene types/, likely on a satellite paper basis

Names put after project lines are should be regarded as a commitment in terms of "we will work on this" but are not excluding other groups

General goals/foci

• Protein space:
  • Given TSS clusters within protein-coding genes, how many are alternative promoters and how many of these are bona fide promoters.
    • How many of these are likely to change promoter function (domains missing?) and are these biased to tissue/cells? (Albin/Julian G).
    • Should also be overlaid with other relevant meta-data - gene ontology, motifs, etc
• Other genomic space that are tissue biased can be analyzed the same way (strictly speaking these are not "alternative promoters" but something else ) (Albin)

Specific goals/foci (relating to sub-sets of tissues or genes)

• Olfactory receptors (both alternative promoters and also atypical tissue expression).
• Alternative promoters within different brain tissues (Heutink )
• Transcription factor genes in terms of domain loss vs tissue bias (Albin)
• Cancer? (Win)

Data sets

Methods