Cerebellum development

Cerebellum development Brain development requires intricately controlled expression of specific gene regulatory networks across time. Despite recent development in genomics technology, temporally-dependent large-scale transcriptome analyses across neural development are lacking. The cerebellum is a less complex, anatomically discrete and well-studied part of the mammalian brain that lends itself to such an analysis. To identify active transcription factor networks in developing mouse cerebellum, we analyzed the sequenced CAGE libraries from 12 time points across cerebellar development (embryonic days 11-18 at 24 hour intervals and every 72hrs until postnatal day 9).

Zenbu configurations and status

• Cerebellum development(COMPLETED ...)

Gene expression profiles

• Known gene expression for the Cerebellum development series
  • TPM
  • tagcount
• Promoterome v1.0 expression for the Cerebellum development series
• Top dynamic TFs in Cerebellum development series

Motifs

• Top dynamic motifs in Cerebellum development series

MARA based network results

• Cerebellum development network based on top 30 dynamic motifs

Related samples

• Adult Cerebellum data
• Cerebellar cell type data such as granule cells
• Other Brain and Neuronal lineage cell type data

References

• Goldowitz, D. and K. Hamre, The cells and molecules that make a cerebellum. Trends Neurosci, 1998. 21(9): p. 375-82.
• Swanson, D.J., Y. Tong, and D. Goldowitz, Disruption of cerebellar granule cell development in the Pax6 mutant, Sey mouse. Brain Res Dev Brain Res, 2005. 160(2): p. 176-93.

Quality control

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