Motif activities for UPDATE 011

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Methodology

Motif activities were calculated for all samples for all five organisms using an approach similar to the MARA analysis developed by Erik and Piotr during FANTOM4. First, transcription factor binding sites were predicted in the -300..+100 base pair region around each level-2 promoter in the UPDATE_011 data set. Phylogeny information was included by using the whole-genome alignments from UCSC. These genome sequences were realigned across organisms using T-Coffee.

Note that the species included in the phylogenetic tree depend on what is available from UCSC, and therefore is different for each organism for which we have data. I used the following organisms:

  • Human: hg19, rheMac2, mm9, rn4, bosTau4, equCab2, canFam2, monDom5, galGal3
  • Mouse: mm9, rn4, hg18, rheMac2, bosTau3, equCab1, canFam2, monDom4, galGal3
  • Rat: rn4, mm8, hg18, canFam2, bosTau2, monDom4, galGal2
  • Dog: canFam2, hg17, mm6, rn3
  • Chicken: galGal3, hg18, mm8, rn4, monDom4

Whether phylogeny information should be included at all, and if so, how, is up for debate, but this is what I did for now.

Next, I associated TFBSs to promoters using a distance profile, which models the positions with respect to the promoter at which TFBSs are typically found. This distance profile is estimated for each motif separately and is based on the overall distribution of predicted TFBS positions with respect to level-2 promoters.

The calculation of the motif activities differs from the methodology used in FANTOM4 in one important aspect. In FANTOM4 (MARA), the average of the expression of each promoter across the samples were subtracted so that the expression of each promoter centers around zero. In my (MASA) calculations for FANTOM5, this subtraction was not made. This allows the motif activities for each sample to be calculated independently from the other samples. However, it is trivial to convert the MASA-defined motif activities to MARA-defined activities: For each motif, calculate and subtract the average of the motif activities over the samples. The result will be identical to what you would have gotten if you had subtracted the sample average from the expression levels of each promoter as done in MARA. Whereas the standard deviations are different in MASA compared to MARA, the MASA ones may be more appropriate, since those standard deviations are independent from each other.

To visually represent the motif activities for each organism, I performed complete-linkage hierarchical clustering on the motifs and on the cell types using the Pearson correlation as the similarity measure. Heat maps for the motif activities are below. I then ranked the motifs by their Z-values in each condition for each organism after subtracting the average across samples from each motif. Below is a table of the first-ranked motif for each organism in each cell type.

Using the motif activities, I also calculated the predicted regulatory network (using the same approach as in FANTOM4).

The table below contains four types of files:

  • assembly.tfbs.gz: The predicted TFBSs for each promoter (from which the motif activities are then calculated)
  • assembly.activities.pdf: The heat map of the motif activities
  • assembly.activities.gz: The motif activities and their standard deviations
  • assembly.network: The transcriptional regulatory network based on the motif activities.

where "assembly" is hg19, mm9, rn4, canFam2, or galGal3.

--Michiel, 2011.05.31

Data files

Organism TFBS predictions Heat map of the motif activities Motif activities Regulatory network calculated from the motif activities
hg19 Media:hg19.update_011.tfbs.gz Media:hg19.update_011.activities.pdf Media:hg19.update_011.activities.gz Media:hg19.update_011.network.gz
mm9 Media:mm9.update_011.tfbs.gz Media:mm9.update_011.activities.pdf Media:mm9.update_011.activities.gz Media:mm9.update_011.network.gz
rn4 Media:rn4.update_011.tfbs.gz Media:rn4.update_011.activities.pdf Media:rn4.update_011.activities.gz Media:rn4.update_011.network.gz
canFam2 Media:canFam2.update_011.tfbs.gz Media:canFam2.update_011.activities.pdf Media:canFam2.update_011.activities.gz Media:canFam2.update_011.network.gz
galGal3 Media:galGal3.update_011.tfbs.gz Media:galGal3.update_011.activities.pdf Media:galGal3.update_011.activities.gz Media:galGal3.update_011.network.gz

Top-ranked motif per organism and cell type

Spearman correlation between the motif activity and the CAGE expression level of the corresponding transcription factor(s)

These correlations were calculated from the motif activities for hg19 above. The list below is sorted from highest correlation to lowest. Overall, there is no clear tendency for the motif activity and the expression levels to be correlated, as shown by the histogram. However, some motifs, such as E2F1..5, show a clear correlation.

See also Correlation between motif activities and TF expression without phylogeny for the same table if the TFBSs are predicted only using the position-weight matrix score, so without using phylogeny information.

Motif expression correlations histogram.png

Motif Transcription factor gene Spearman correlation Scatter plot
E2F1..5 E2F1 0.829623 [[1]]
FOS_FOS_B,L1__JUN_B,D_ FOSL1 0.714978 [[2]]
E2F1..5 E2F3 0.695520 [[3]]
E2F1..5 E2F2 0.670895 [[4]]
IRF1,2 IRF2 0.653570 [[5]]
CREB1 CREB1 0.630771 [[6]]
TEAD1 TEAD1 0.623533 [[7]]
NFKB1_REL_RELA NFKB1 0.565934 [[8]]
TFDP1 TFDP1 0.561395 [[9]]
E2F1..5 E2F4 0.551080 [[10]]
NFY_A,B,C_ NFYC 0.548235 [[11]]
IRF1,2 IRF1 0.541262 [[12]]
ELK1,4_GABP_A,B1_ GABPB1 0.521740 [[13]]
RFX2..5_RFXANK_RFXAP RFX3 0.519881 [[14]]
RUNX1..3 RUNX3 0.477065 [[15]]
YY1 YY1 0.476948 [[16]]
NFY_A,B,C_ NFYA 0.471183 [[17]]
MEF2_A,B,C,D_ MEF2C 0.457441 [[18]]
CEBPA,B_DDIT3 DDIT3 0.454064 [[19]]
ELK1,4_GABP_A,B1_ GABPA 0.449807 [[20]]
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1 MYC 0.449451 [[21]]
ELF1,2,4 ELF1 0.447875 [[22]]
SMAD1..7,9 SMAD9 0.447281 [[23]]
CEBPA,B_DDIT3 CEBPB 0.445712 [[24]]
HAND1,2 HAND2 0.442099 [[25]]
FOXL1 FOXL1 0.428972 [[26]]
RUNX1..3 RUNX2 0.428124 [[27]]
NFE2L1 NFE2L1 0.415170 [[28]]
ESRRA ESRRA 0.410353 [[29]]
MYB MYB 0.409904 [[30]]
NFY_A,B,C_ NFYB 0.408547 [[31]]
LEF1_TCF7_TCF7L1,2 TCF7L1 0.407103 [[32]]
STAT1,3 STAT1 0.398179 [[33]]
SP1 SP1 0.395857 [[34]]
PRRX1,2 PRRX1 0.392919 [[35]]
EBF1 EBF1 0.382614 [[36]]
IRF7 IRF7 0.376065 [[37]]
DBP DBP 0.367487 [[38]]
ELK1,4_GABP_A,B1_ ELK1 0.360164 [[39]]
ZNF143 ZNF143 0.359320 [[40]]
ETS1,2 ETS1 0.343801 [[41]]
JUN JUN 0.342486 [[42]]
RBPJ RBPJ 0.323575 [[43]]
FOXP1 FOXP1 0.321931 [[44]]
FOS_FOS_B,L1__JUN_B,D_ JUNB 0.317805 [[45]]
NKX3-1 NKX3-1 0.314450 [[46]]
SPIB SPIB 0.311856 [[47]]
SPI1 SPI1 0.308550 [[48]]
HBP1_HMGB_SSRP1_UBTF HBP1 0.304783 [[49]]
MYBL2 MYBL2 0.304652 [[50]]
RXRA_VDR_dimer_ VDR 0.303961 [[51]]
MYFfamily MYOD1 0.301876 [[52]]
MYFfamily MYF6 0.296866 [[53]]
FOXP3 FOXP3 0.295781 [[54]]
PRRX1,2 PRRX2 0.295402 [[55]]
ATF4 ATF4 0.290789 [[56]]
SMAD1..7,9 SMAD6 0.288100 [[57]]
HNF4A_NR2F1,2 NR2F1 0.284023 [[58]]
MYFfamily MYF5 0.283171 [[59]]
SOX17 SOX17 0.279350 [[60]]
NFKB1_REL_RELA REL 0.274631 [[61]]
RFX2..5_RFXANK_RFXAP RFXAP 0.271255 [[62]]
SOX2 SOX2 0.262198 [[63]]
HNF1A HNF1A 0.258667 [[64]]
ZNF384 ZNF384 0.257292 [[65]]
RXR_A,B,G___NR1H2,PPAR_dimers PPARG 0.256317 [[66]]
NFKB1_REL_RELA RELA 0.251869 [[67]]
FOX_F1,F2,J1_ FOXJ1 0.249899 [[68]]
NFATC1..3 NFATC1 0.247487 [[69]]
HNF4A_NR2F1,2 HNF4A 0.247103 [[70]]
MEF2_A,B,C,D_ MEF2A 0.239441 [[71]]
ELF1,2,4 ELF4 0.237373 [[72]]
SMAD1..7,9 SMAD7 0.235660 [[73]]
HBP1_HMGB_SSRP1_UBTF HMGB3 0.234378 [[74]]
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1 USF1 0.234299 [[75]]
STAT2,4,6 STAT2 0.231885 [[76]]
MEF2_A,B,C,D_ MEF2D 0.230964 [[77]]
HMGA1,2 HMGA1 0.229020 [[78]]
HNF4A_NR2F1,2 NR2F2 0.227899 [[79]]
SMAD1..7,9 SMAD1 0.227341 [[80]]
PPARG PPARG 0.222281 [[81]]
FOSL2 FOSL2 0.221104 [[82]]
RFX1 RFX1 0.214960 [[83]]
FOXO1,3,4 FOXO4 0.214380 [[84]]
SNAI1..3 SNAI3 0.212785 [[85]]
HIC1 HIC1 0.210817 [[86]]
RFX2..5_RFXANK_RFXAP RFX2 0.208149 [[87]]
MAFB MAFB 0.207511 [[88]]
HBP1_HMGB_SSRP1_UBTF HMGB2 0.207005 [[89]]
STAT2,4,6 STAT6 0.206426 [[90]]
EGR1..3 EGR2 0.204156 [[91]]
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1 ARNT 0.203050 [[92]]
RFX2..5_RFXANK_RFXAP RFX5 0.190272 [[93]]
SRF SRF 0.189861 [[94]]
ZFP161 ZFP161 0.187739 [[95]]
STAT2,4,6 STAT4 0.181456 [[96]]
TP53 TP53 0.178904 [[97]]
POU2F1..3 POU2F1 0.178173 [[98]]
FOXO1,3,4 FOXO1 0.177905 [[99]]
DMAP1_NCOR_1,2__SMARC SMARCA5 0.176741 [[100]]
FOXO1,3,4 FOXO3 0.176491 [[101]]
PAX6 PAX6 0.176228 [[102]]
EGR1..3 EGR3 0.175699 [[103]]
SMAD1..7,9 SMAD3 0.175499 [[104]]
GTF2A1,2 GTF2A2 0.175375 [[105]]
NHLH1,2 NHLH2 0.166407 [[106]]
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1 MAX 0.165585 [[107]]
NKX2-3_NKX2-5 NKX2-5 0.164186 [[108]]
SREBF1,2 SREBF2 0.162755 [[109]]
DMAP1_NCOR_1,2__SMARC NCOR1 0.160522 [[110]]
CEBPA,B_DDIT3 CEBPA 0.158703 [[111]]
VSX1,2 VSX2 0.157054 [[112]]
EP300 EP300 0.154948 [[113]]
NFIL3 NFIL3 0.151202 [[114]]
POU3F1..4 POU3F2 0.151120 [[115]]
TFAP2_A,C_ TFAP2C 0.149681 [[116]]
ATF2 ATF2 0.147103 [[117]]
FOXQ1 FOXQ1 0.146389 [[118]]
CRX CRX 0.141528 [[119]]
SOX_8,9,10_ SOX8 0.137807 [[120]]
SOX_8,9,10_ SOX10 0.137669 [[121]]
TFAP2B TFAP2B 0.136351 [[122]]
TLX1..3_NFIC_dimer_ TLX1 0.136019 [[123]]
HMGA1,2 HMGA2 0.135881 [[124]]
FOXM1 FOXM1 0.133094 [[125]]
HAND1,2 HAND1 0.125583 [[126]]
GFI1 GFI1 0.124505 [[127]]
RUNX1..3 RUNX1 0.121457 [[128]]
STAT1,3 STAT3 0.120527 [[129]]
REST REST 0.120189 [[130]]
PDX1 PDX1 0.119565 [[131]]
GLI1..3 GLI3 0.119057 [[132]]
PRDM1 PRDM1 0.116870 [[133]]
AHR_ARNT_ARNT2 ARNT 0.115626 [[134]]
NKX3-2 NKX3-2 0.115463 [[135]]
KLF4 KLF4 0.113869 [[136]]
ETS1,2 ETS2 0.112488 [[137]]
E2F1..5 E2F5 0.111446 [[138]]
TAL1_TCF_3,4,12_ TCF3 0.111407 [[139]]
FOX_C1,C2_ FOXC2 0.110195 [[140]]
GTF2I GTF2I 0.109469 [[141]]
TFAP2_A,C_ TFAP2A 0.105821 [[142]]
SOX_8,9,10_ SOX9 0.105118 [[143]]
ESR1 ESR1 0.104577 [[144]]
RXR_A,B,G___NR1H2,PPAR_dimers RXRB 0.103546 [[145]]
GTF2A1,2 GTF2A1 0.103509 [[146]]
LEF1_TCF7_TCF7L1,2 TCF7L2 0.103100 [[147]]
NKX2-1,4 NKX2-1 0.102434 [[148]]
NHLH1,2 NHLH1 0.101820 [[149]]
LHX3,4 LHX3 0.099966 [[150]]
JUN JUND 0.098115 [[151]]
HBP1_HMGB_SSRP1_UBTF SSRP1 0.094847 [[152]]
HBP1_HMGB_SSRP1_UBTF UBTF 0.093336 [[153]]
RXR_A,B,G___NR1H2,PPAR_dimers RXRA 0.092502 [[154]]
RFX2..5_RFXANK_RFXAP RFX4 0.091932 [[155]]
HOX_A5,B5_ HOXB5 0.088844 [[156]]
HMX1 HMX1 0.084997 [[157]]
ADNP_IRX_SIX_ZHX ADNP 0.084302 [[158]]
NR5A1,2 NR5A2 0.083699 [[159]]
FOS_FOS_B,L1__JUN_B,D_ FOSB 0.083607 [[160]]
OCT4_SOX2_dimer_ SOX2 0.081553 [[161]]
NKX2-2,8 NKX2-2 0.081402 [[162]]
RXR_A,B,G_ RXRG 0.078677 [[163]]
ALX4 ALX4 0.075822 [[164]]
JUN JUNB 0.073653 [[165]]
ZBTB6 ZBTB6 0.070710 [[166]]
POU5F1 POU5F1 0.067180 [[167]]
FOXD3 FOXD3 0.066023 [[168]]
POU2F1..3 POU2F3 0.065855 [[169]]
POU2F1..3 POU2F2 0.064504 [[170]]
NKX2-3_NKX2-5 NKX2-3 0.059965 [[171]]
RXR_A,B,G___NR1H2,PPAR_dimers NR1H2 0.056413 [[172]]
SMAD1..7,9 SMAD4 0.055455 [[173]]
FOXA2 FOXA2 0.053494 [[174]]
RXR_A,B,G_ RXRB 0.053335 [[175]]
LHX3,4 LHX4 0.047763 [[176]]
PITX1..3 PITX1 0.046918 [[177]]
NR5A1,2 NR5A1 0.039916 [[178]]
GLI1..3 GLI1 0.037322 [[179]]
bHLH_family ARNTL 0.037151 [[180]]
NR1H4 NR1H4 0.036911 [[181]]
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1 ARNT2 0.036445 [[182]]
bHLH_family MITF 0.035306 [[183]]
bHLH_family MXI1 0.034314 [[184]]
bHLH_family OLIG2 0.033408 [[185]]
bHLH_family OLIG1 0.033370 [[186]]
CUX2 CUX2 0.031211 [[187]]
TLX1..3_NFIC_dimer_ TLX3 0.030435 [[188]]
NANOG NANOG 0.030254 [[189]]
OCT4_SOX2_dimer_ POU5F1 0.030013 [[190]]
EGR1..3 EGR1 0.029908 [[191]]
NKX2-1,4 NKX2-4 0.029774 [[192]]
bHLH_family MXD3 0.028690 [[193]]
TBX4,5 TBX5 0.027836 [[194]]
AHR_ARNT_ARNT2 AHR 0.027112 [[195]]
GATA4 GATA4 0.026901 [[196]]
bHLH_family HEY1 0.026051 [[197]]
MAZ MAZ 0.025370 [[198]]
bHLH_family HES6 0.023800 [[199]]
FOS_FOS_B,L1__JUN_B,D_ FOS 0.022680 [[200]]
SPZ1 SPZ1 0.021260 [[201]]
NR6A1 NR6A1 0.018628 [[202]]
XBP1 XBP1 0.017821 [[203]]
PAX2 PAX2 0.017571 [[204]]
ONECUT1,2 ONECUT2 0.017164 [[205]]
ADNP_IRX_SIX_ZHX ZHX2 0.016936 [[206]]
HSF1,2 HSF2 0.016804 [[207]]
NKX2-2,8 NKX2-8 0.013328 [[208]]
VSX1,2 VSX1 0.010673 [[209]]
EN1,2 EN2 0.009025 [[210]]
ONECUT1,2 ONECUT1 0.005565 [[211]]
ADNP_IRX_SIX_ZHX ZHX3 0.005528 [[212]]
NR3C1 NR3C1 0.004483 [[213]]
POU3F1..4 POU3F1 0.004043 [[214]]
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1 BHLHB2 0.002753 [[215]]
ARID5B ARID5B 0.000323 [[216]]
TFCP2 TFCP2 -0.000264 [[217]]
ADNP_IRX_SIX_ZHX ZHX1 -0.001989 [[218]]
GATA1..3 GATA1 -0.003727 [[219]]
AHR_ARNT_ARNT2 ARNT2 -0.004186 [[220]]
TLX2 TLX2 -0.008470 [[221]]
SMAD1..7,9 SMAD5 -0.010747 [[222]]
ADNP_IRX_SIX_ZHX IRX4 -0.010748 [[223]]
STAT5_A,B_ STAT5A -0.015004 [[224]]
NANOG_mouse_ NANOG -0.015023 [[225]]
LEF1_TCF7_TCF7L1,2 TCF7 -0.019443 [[226]]
BACH2 BACH2 -0.020007 [[227]]
POU1F1 POU1F1 -0.021576 [[228]]
RXR_A,B,G___NR1H2,PPAR_dimers PPARA -0.031348 [[229]]
RFX2..5_RFXANK_RFXAP RFXANK -0.035279 [[230]]
DMAP1_NCOR_1,2__SMARC SMARCC2 -0.040969 [[231]]
bHLH_family HEY2 -0.041269 [[232]]
ALX1 ALX1 -0.043238 [[233]]
FOX_C1,C2_ FOXC1 -0.045367 [[234]]
PATZ1 PATZ1 -0.046062 [[235]]
NFATC1..3 NFATC2 -0.049580 [[236]]
AR AR -0.050390 [[237]]
SOX5 SOX5 -0.050729 [[238]]
MZF1 MZF1 -0.051084 [[239]]
GATA1..3 GATA3 -0.059869 [[240]]
GATA1..3 GATA2 -0.060931 [[241]]
NKX6-1,2 NKX6-1 -0.063217 [[242]]
TEF TEF -0.069323 [[243]]
ATF6 ATF6 -0.069824 [[244]]
PAX8 PAX8 -0.070721 [[245]]
ADNP_IRX_SIX_ZHX IRX5 -0.070788 [[246]]
SNAI1..3 SNAI1 -0.071247 [[247]]
ZNF238 ZNF238 -0.073581 [[248]]
HOX_A5,B5_ HOXA5 -0.073602 [[249]]
AIRE AIRE -0.076635 [[250]]
ZIC1..3 ZIC1 -0.077676 [[251]]
bHLH_family HEYL -0.078174 [[252]]
HOX_A4,D4_ HOXA4 -0.078721 [[253]]
SMAD1..7,9 SMAD2 -0.080464 [[254]]
ATF5_CREB3 ATF5 -0.080900 [[255]]
GFI1B GFI1B -0.083927 [[256]]
PITX1..3 PITX2 -0.084860 [[257]]
bHLH_family MXD4 -0.086173 [[258]]
EVI1 EVI1 -0.087601 [[259]]
TFAP4 TFAP4 -0.089109 [[260]]
HSF1,2 HSF1 -0.089881 [[261]]
CDC5L CDC5L -0.092356 [[262]]
FOX_F1,F2,J1_ FOXF2 -0.093637 [[263]]
IKZF2 IKZF2 -0.096372 [[264]]
FOX_I1,J2_ FOXI1 -0.098579 [[265]]
MYOD1 MYOD1 -0.101267 [[266]]
CDX1,2,4 CDX2 -0.108824 [[267]]
FOX_D1,D2_ FOXD1 -0.110191 [[268]]
ZIC1..3 ZIC3 -0.111502 [[269]]
SREBF1,2 SREBF1 -0.113116 [[270]]
NKX6-1,2 NKX6-2 -0.114020 [[271]]
KLF12 KLF12 -0.114372 [[272]]
SNAI1..3 SNAI2 -0.121735 [[273]]
RXR_A,B,G___NR1H2,PPAR_dimers RXRG -0.131987 [[274]]
ADNP_IRX_SIX_ZHX SIX2 -0.133686 [[275]]
ADNP_IRX_SIX_ZHX SIX5 -0.134838 [[276]]
DMAP1_NCOR_1,2__SMARC DMAP1 -0.137853 [[277]]
PAX5 PAX5 -0.138600 [[278]]
HOXA9_MEIS1 HOXA9 -0.139634 [[279]]
POU3F1..4 POU3F3 -0.143202 [[280]]
NFE2 NFE2 -0.144688 [[281]]
POU3F1..4 POU3F4 -0.145403 [[282]]
PAX3,7 PAX3 -0.145795 [[283]]
PITX1..3 PITX3 -0.149769 [[284]]
bHLH_family MLXIPL -0.153629 [[285]]
FOS_FOS_B,L1__JUN_B,D_ JUND -0.155940 [[286]]
NFE2L2 NFE2L2 -0.161056 [[287]]
PAX1,9 PAX9 -0.161567 [[288]]
TAL1_TCF_3,4,12_ TCF4 -0.165004 [[289]]
HLF HLF -0.166157 [[290]]
PAX3,7 PAX7 -0.177863 [[291]]
DMAP1_NCOR_1,2__SMARC NCOR2 -0.178398 [[292]]
GATA6 GATA6 -0.180433 [[293]]
HIF1A HIF1A -0.186996 [[294]]
NFATC1..3 NFATC3 -0.188976 [[295]]
RXR_A,B,G_ RXRA -0.193948 [[296]]
GCM1,2 GCM1 -0.196002 [[297]]
STAT5_A,B_ STAT5B -0.201070 [[298]]
bHLH_family MNT -0.206078 [[299]]
CDX1,2,4 CDX1 -0.211231 [[300]]
FOX_F1,F2,J1_ FOXF1 -0.218504 [[301]]
GCM1,2 GCM2 -0.218732 [[302]]
FOX_I1,J2_ FOXJ2 -0.220500 [[303]]
MSX1,2 MSX1 -0.222794 [[304]]
HOX_A6,A7,B6,B7_ HOXB7 -0.231175 [[305]]
ZBTB16 ZBTB16 -0.234785 [[306]]
MSX1,2 MSX2 -0.247271 [[307]]
LEF1_TCF7_TCF7L1,2 LEF1 -0.254616 [[308]]
PBX1 PBX1 -0.256732 [[309]]
TBP TBP -0.256763 [[310]]
MTF1 MTF1 -0.257705 [[311]]
HOX_A6,A7,B6,B7_ HOXB6 -0.275674 [[312]]
bHLH_family CLOCK -0.280199 [[313]]
bHLH_family TFE3 -0.283201 [[314]]
BPTF BPTF -0.288047 [[315]]
HOX_A6,A7,B6,B7_ HOXA7 -0.293840 [[316]]
bHLH_family ARNTL2 -0.309900 [[317]]
RREB1 RREB1 -0.323322 [[318]]
bHLH_family ID1 -0.326505 [[319]]
ZEB1 ZEB1 -0.328956 [[320]]
PAX1,9 PAX1 -0.330693 [[321]]
HOXA9_MEIS1 MEIS1 -0.342259 [[322]]
DMAP1_NCOR_1,2__SMARC SMARCA1 -0.372657 [[323]]
bHLH_family NPAS2 -0.388028 [[324]]
HES1 HES1 -0.417659 [[325]]
ATF5_CREB3 CREB3 -0.420408 [[326]]
ZNF148 ZNF148 -0.427910 [[327]]
IKZF1 IKZF1 -0.433240 [[328]]
ZIC1..3 ZIC2 -0.439631 [[329]]
TGIF1 TGIF1 -0.469242 [[330]]
TAL1_TCF_3,4,12_ TCF12 -0.477845 [[331]]
NFIX NFIX -0.531952 [[332]]
TOPORS TOPORS -0.548742 [[333]]
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